Hepathoprotective and dezintoxictional effect of medicine «Hamavit» and «Fospreniol» under direct and administrative application in the poultry

Abstract

Changes in the biochemical composition of blood among hens during experimental eimeriosis reflect the development of pathological processes in their bodies. Taking into account that eimeria affect not only the epithelial cells of the intestinal mucosa, but cause deep morphofunctional changes in the liver, we have studied the protein synthesis and detoxification properties of the chickens during the experimental eimeriosis. To solve the problems, the study was conducted on the chickens, which, by analogy, were divided into 6 groups: control (K) and 5 experimental (D1–D5) with 8 chickens in each. At the beginning of the experiment their age was 4 weeks. They were fed by the mixed fodder. Accordingly, experimental chickens from the first to fifth experimental groups were infected by Eimerioid invasion. At the same time, the experimental bird of the 1st group (D1) was not processed by the eimiriocidal agent, and for the following four (D2–D5) as a parasitic agent, a new remedy Brovafom new was given, which was prescribed 2 g per kg of the mixed fodder feed during 7 days. In addition, in order to ensure the rapid recovery of the poultry organism after an application of the antiparasitic remedy, chickens from the third (D3) and fourth (D4) experimental groups were given Gamavit and Fosprenil during 7 days in doses of 2.5 ml per 1 liter of water. We have found out that in the serum of blood of chickens from the experimental groups a low level of total protein and especially its protein fraction was presented. In addition, the concentration of uric acid and creatinine increased in the poultry blood and increased activity of AlAT and AsAT. The most effective and cost-effective methods of combating eimeriosis is the use of chemical drugs that delay or detrimental effect on the eimeria (eimeriosis) effects at the endogenous stages of development. After the application of the therapeutic purpose of the eimeriostatic remedy «Brovaf new» eliminates the negative effects of toxins on hepatocytes of the liver. It is noted that complete restoration of the functional state of the liver is not achieved. Rather and more efficiently, this process takes place during the bird products with medicine Gamavit and Fosprenil, with the best result and with a lower dose achieved through their combined use