Abstract
We analyzed more than 30 original articles and reviews to evaluate the current state of the issues of epidemiology, treatment, and prevention of hemorrhagic fever with renal syndrome in the world. A literature search was conducted using the Cochrane Library, PubMed, eLIBRARY databases and official WHO, UR Rospotrebnadzor, Rospotrebnadzor of the Russian Federation, and Center for Disease Control and Prevention data. Hemorrhagic fever with renal syndrome (HFRS) is an acute infectious disease characterized by fever, hemodynamic disorders, hemorrhagic syndrome and kidney damage in the form of acute interstitial nephritis with the development of acute kidney injury. It is caused by RNA-containing viruses of the Hantaan genus, belongs to the group of zoonotic infections, and is transmitted through the air. The Udmurt Republic is one of the regions of the Volga Federal District endemic for HFRS. Annually, from 300 to 2,000 people get sick in the territory of the republic. HFRS affects the most able-bodied part of the population, mainly men aged 20-50. Mortality reaches 20% in certain years of observation. The doctor’s lack of caution regarding HFRS (the initial period of the disease has similar symptoms with acute respiratory diseases) leads to late hospitalization of the patient, often with serious complications that are fatal. The main diagnostic search is carried out by the general practice service of the outpatient clinic. The materials of the article can help to correctly establish a preliminary diagnosis, taking into account clinical and epidemiological data, as well as to prescribe the necessary amount of laboratory and instrumental tests to clarify the diagnosis.
Highlights
We analyzed more than 30 original articles and reviews to evaluate the current state of the issues of epidemiology, treatment, and prevention of hemorrhagic fever with renal syndrome in the world
Hemorrhagic fever with renal syndrome (HFRS) is an acute infectious disease characterized by fever, hemodynamic disorders, hemorrhagic syndrome and kidney damage in the form of acute interstitial nephritis with the development of acute kidney injury
Borodina Zh.I. Some clinical and pathogenetic aspects of intoxication in hemorrhagic fever with renal syndrome
Summary
Федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации, Ижевск, Россия. В работе было проанализировано более 30 оригинальных статей и обзоров с целью изучения современного состояния вопросов эпидемиологии, лечения, профилактики геморрагической лихорадки с почечным синдромом в мире. Поиск литературы проводился по базам данных The Cochrane Library, PubMed, eLIBRARY, использовались официальная информация Всемирной организации здравоохранения, Управления Роспотребнадзора по Удмуртской Республике, Управления Роспотребнадзора Российской Федерации, Centers for Disease Control and Prevention. Геморрагическая лихорадка с почечным синдромом (ГЛПС) — острое инфекционное заболевание, характеризующееся лихорадкой, гемодинамическими расстройствами, геморрагическим синдромом и поражением почек по типу острого интерстициального нефрита с развитием острой почечной недостаточности. Удмуртская республика является одним из эндемичных по ГЛПС регионов Приволжского федерального округа. Ключевые слова: геморрагическая лихорадка с почечным синдромом, современное клиническое течение, полиморфизм генов, патогенез, этиотропная терапия ГЛПС, вакцинация
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