Abstract
Hemophagocytic Lymphohistiocytosis and Progressive Disseminated Histoplasmosis.
Highlights
We report a case of simultaneous Progressive disseminated histoplasmosis (PDH) and hemophagocytic lymphohistiocytosis (HLH) in an infant
Familial HLH is caused by mutations in >1 of the genes required for perforin-dependent lymphocyte cytotoxicity; secondary HLH occurs in a person who does not have genetic risk factors [3]
Laboratory tests specific for HLH, such as measuring soluble interleukin-2 receptor, have not been investigated in patients with isolated PDH, so whether they distinguish between the 2 conditions is unclear
Summary
Jude Children’s Research Hospital in April 2015 with a 1-month history of daily fever Her history was notable only for a methicillin-resistant Staphylococcus aureus skin abscess diagnosed when she was 5 months old; it was drained, and she received oral clindamycin. Supportive care included transfusion of packed red blood cells, platelets, cryoprecipitate, and fresh frozen plasma Her fever resolved after 10 days, and other symptoms resolved after 2 weeks. Familial HLH is caused by mutations in >1 of the genes required for perforin-dependent lymphocyte cytotoxicity; secondary HLH occurs in a person who does not have genetic risk factors [3] Both forms can be triggered by infection or malignancy [3].
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