Hemolymph of Baikal endemic crustacean Eulimnogammarus verrucosus as a source for novel natural products

Abstract

Event Abstract Back to Event Hemolymph of Baikal endemic crustacean Eulimnogammarus verrucosus as a source for novel natural products Denis Axenov-Gribanov1, 2*, Eugenii Protasov1, Polina Drozdova1, Kseniya Vereshchagina1, Yuliya Lubyaga1, Zhanna Shatilina1 and Maxim Timofeyev1 1 Irkutsk State University, Russia 2 Baikal Research Center, Russia Background Antibiotic resistance and targeted therapy are one of the most important and worldwide issues. Extreme and unusual ecosystems such as Lake Baikal and its inhabitant are considered as potential tools for the discovery of novel natural products with biological activities. The aim of this study was to assess the possibility to use Baikal endemic amphipods as a source for screening of novel natural products. Methods Analysis of hemolymph from an amphipod Eulimnogammarus verrucosus by HPLC-MS was performed for the first time and allowed us to find a number of natural products with new molecular mass values for Baikal endemic macroinvertebrates. Results We identified a compound as chrysin by comparison of MS1, MS2 profiles and molecular masses of natural products registered in Dictionary of Natural Products and MZ-cloud databases. Also, we found a new compound with a mass of 493.80277 Da and a number of antimicrobial peptides circulating in the amphipod hemolymph. Conclusion Thus, we confirmed that the hemolymph of Baikal endemic crustacean E. verrucosus is a source of novel natural products and could have biotechnological value for pharmacy and biomedicine. Acknowledgements This study was carried out with partial financial support of the RSF project (18-74-00018), RFBR project (16-34-60060), projects of the Ministry of Education and Science of the Russian Federation 6.9654.2017/8.9, 6.12738.2018/12.2, 6.12736.2018/12.2, and the Lake Baikal Foundation. Keywords: Baikal, amphipods, endemics, Natural Products, Eulimnogammarus verrucosus Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Poster Presentation Topic: Infectious diseases Citation: Axenov-Gribanov D, Protasov E, Drozdova P, Vereshchagina K, Lubyaga Y, Shatilina Z and Timofeyev M (2019). Hemolymph of Baikal endemic crustacean Eulimnogammarus verrucosus as a source for novel natural products. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2019.63.00041 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Sep 2018; Published Online: 17 Jan 2019. * Correspondence: Mr. Denis Axenov-Gribanov, Irkutsk State University, Irkutsk, Russia, Denis.axengri@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Denis Axenov-Gribanov Eugenii Protasov Polina Drozdova Kseniya Vereshchagina Yuliya Lubyaga Zhanna Shatilina Maxim Timofeyev Google Denis Axenov-Gribanov Eugenii Protasov Polina Drozdova Kseniya Vereshchagina Yuliya Lubyaga Zhanna Shatilina Maxim Timofeyev Google Scholar Denis Axenov-Gribanov Eugenii Protasov Polina Drozdova Kseniya Vereshchagina Yuliya Lubyaga Zhanna Shatilina Maxim Timofeyev PubMed Denis Axenov-Gribanov Eugenii Protasov Polina Drozdova Kseniya Vereshchagina Yuliya Lubyaga Zhanna Shatilina Maxim Timofeyev Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.