Abstract
In 2005, the International Lipid Classification and Nomenclature Committee under the sponsorship of the LIPID MAPS Consortium developed and established a "Comprehensive Classification System for Lipids" based on well-defined chemical and biochemical principles and using an ontology that is extensible, flexible, and scalable. This classification system, which is compatible with contemporary databasing and informatics needs, has now been accepted internationally and widely adopted. In response to considerable attention and requests from lipid researchers from around the globe and in a variety of fields, the comprehensive classification system has undergone significant revisions over the last few years to more fully represent lipid structures from a wider variety of sources and to provide additional levels of detail as necessary. The details of this classification system are reviewed and updated and are presented here, along with revisions to its suggested nomenclature and structure-drawing recommendations for lipids.
Highlights
Nomenclature Committee (ILCNC) developed a “Comprehensive Classification System for Lipids” that was published in 2005 [1]
The list of subclasses under the Sterols main class has been expanded to include a set of 15 different core structures (Ergosterols, Gorgosterols, Furostanols, etc.), which provide a structure-based classification of these molecules that span multiple phyla
We have developed a large publicly available comprehensive object-relational database of lipid structures through integration of lipid molecules from existing repositories and from the LIPID MAPS project
Summary
H. Raetz,†† Takao Shimizu,§§ Friedrich Spener,*** Gerrit van Meer,††† Michael J. San Diego Supercomputer Center,* Department of Bioengineering,† and Department of Chemistry and Biochemistry and Department of Pharmacology of the School of Medicine,**** University of California, San Diego, La Jolla, CA 92093-0505; Department of Pharmacology,§ University of Colorado Denver, Aurora, CO 80045-0598; National Institute of Health Sciences,** Setagaya-ku, Tokyo 158-8501, Japan; Department of Biochemistry,†† Duke University Medical Center, Durham, NC 27710; Department of Biochemistry and Molecular Biology,§§ Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan; Department of Molecular Biosciences,*** University of Graz, 8010 Graz, Austria; Bijvoet Center and Institute of Biomembranes,††† Utrecht University, 3584 CH Utrecht, The Netherlands; and The Babraham Institute,§§§
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