Hemogram Parametrelerinin Antagonist Protokollü IVF-ICSI Siklus Başarısını Öngörmede Etkisi

Abstract

Objective: In IVF-ICSI cycles with GnRH antagonist protocol, it was aimed to investigate the effects of hCG day hemogram values on OPU and IVF-ICSI success, implantation and clinical pregnancy rates. Methods: Patients who underwent IVF-embryo transfer (ET) cycle after controlled ovarian stimulation (COS) ICSI treatment in a secondary care center between 2019 and 2020 were retrospectively screened. The effects of the differences in Hgb, HCT, Plt, WBC, P-LCR, PDW, RDW-CV, RDW-SD, and MPV values, which are among the hCG day CBC parameters of the cases, on the total oocyte (immature (M1)+mature (M2)+ germinal vesicle (GV)) and M2 oocyte counts obtained after OPU, the number of fertilized oocytes (two pronuclei (2PN)) obtained after IVF-ICSI, implantation and clinical pregnancy rates were evaluated. Results: During the study, 171 patients were evaluated. No significant correlations were found between the Hgb, HCT, WBC, P-LCR, PDW and MPV values of the cases and the number of aspirated follicles, total oocytes and M2 oocytes after OPU (p>0.05). No significant correlations were found between the number of 2PN and freeze embryos obtained after IVF-ICSI, implantation and clinical pregnancy rates (p>0.05). A negative, low or insignificantly strong statistically significant correlation (r=-0.160 and p=0.037) was found between the platelet count and the number of follicles aspirated after OPU. It was observed that there were negative, low or insignificantly strong statistically significant correlations between the RDW-CV values of the cases and the number of 2PN and freeze embryos obtained after IVF-ICSI (r=-0.164, p=0.032 and r=-0.224, p=0.004, respectively). In addition, negative, low or insignificantly strong statistically significant correlations were found between the RDW-SD value and the number of follicles aspirated after OPU, total oocytes, and M2 oocytes (r=-0.247, p=0.001; r=-0.24, p=0.003; r=-0.220, p=0.004 respectively). Negative, low or insignificantly strong statistically significant correlations were found between the RDW-SD value and the number of 2PN, and freeze embryos obtained after IVF-ICSI (r=-0.219, p=0.004; r=-0.229, p=0.003 respectively). Conclusion: In conclusion, no significant correlation could be found between women's hCG day Hgb, Hct, WBC, P-LCR, PDW and MPV values and OPU results or IVF-ICSI success, and these values were not predictive during the treatment process. It was determined that none of the hemogram parameters affected the implantation or clinical pregnancy rates in the treatment cycles. Although we found that OPU results worsened with increasing Plt or RDW-SD values, and fertilization success decreased with increasing RDW-SD and RDW-CV values, the strength of these correlations was weak.