Hemodynamic study of fetal growth restriction

Abstract

Objective To investigate the clinical value of fetal blood flow measurement in predicting perinatal outcome of fetuses with intrauterine growth restriction. Methods According to random number table method, 50 pregnant women with fetal growth restriction were selected as case group, and at the same time, 50 normal pregnant women were selected as control group. The fetal umbilical artery, middle cerebral artery and renal artery in pregnant women were detected by color ultrasound Doppler. Results The umbilical artery blood flow of FGR end systolic peak value and the end-diastolic peak ratio S/D, middle cerebral artery blood flow S/D, the prevalence of abnormal renal artery blood flow S/D ratio in the case group were obviously higher than those in the control group, and the differences were significant (P<0.05). The umbilical artery blood flow S/D in the fetus with abnormal hemodynamics in FGR was negatively correlated with the S/D ratio in the middle cerebral artery blood flow(r=-5.325, P<0.05), and it was positively correlated with the S/D ratio in the renal artery blood flow(r=7.325, P<0.05). The incidences of mild asphyxia and severe asphyxia in the case group were significantly higher than that in the control group, and the differences were significant (P<0.05). Conclusions The combined detection of limited growth of fetal umbilical artery, middle cerebral artery and renal artery hemodynamics indexes, help evaluate the fetus-placental circulation and fetal brain and kidney blood circulation situation at the first time, accomplish early detection and early treatment of abnormal cases, to guide clinical termination time, and improve the perinatal outcomes. Key words: Growth restriction; Umbilical artery; Middle cerebral artery; Renal artery