Hemodynamic studies of dogs under pentobarbital and morphine chloralose anesthesia

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Some hemodynamic functions under pentobarbital and morphine-chloralose anesthesia in dogs are described and compared. Under pentobarbital, neither the cardiac output nor the oxygen uptake was related to body weight. These correlations in the dogs that had received morphine-chloralose were somewhat better. With pentobarbital there was a significantly greater cardiac rate and lower stroke volume than with morphine-chloralose. The two agents did not have significantly different effects upon systemic blood pressure, arteriovenous oxygen difference or cardiac output. Changes in cardiac output over a single hour were of sufficient magnitude to account for failure to arrive at a “normal” cardiac output per kg. for the dog anesthetized with pentobarbital or morphine-chloralose. The principal advantage of morphine-chloralose over pentobarbital was the absence of pronounced tachycardia. Some hemodynamic functions under pentobarbital and morphine-chloralose anesthesia in dogs are described and compared. Under pentobarbital, neither the cardiac output nor the oxygen uptake was related to body weight. These correlations in the dogs that had received morphine-chloralose were somewhat better. With pentobarbital there was a significantly greater cardiac rate and lower stroke volume than with morphine-chloralose. The two agents did not have significantly different effects upon systemic blood pressure, arteriovenous oxygen difference or cardiac output. Changes in cardiac output over a single hour were of sufficient magnitude to account for failure to arrive at a “normal” cardiac output per kg. for the dog anesthetized with pentobarbital or morphine-chloralose. The principal advantage of morphine-chloralose over pentobarbital was the absence of pronounced tachycardia.