Abstract
Hemodynamic responses to physostigmine were evaluated in eight patients with coma due to overdose with mainly anticholinergic drugs (AC) and in five patients with coma due to overdose with nonanticholinergic drugs (NAC). After correction of hypovolemia, but before administration of physostigmine, AC patients had significantly lower systemic vascular resistances, slightly higher cardiac outputs, and lower mean arterial pressures than NAC patients. Physostigmine produced negligible hemodynamic and, as expected, negligible neurological changes in NAC patients. In AC patients physostigmine produced, also as expected, improved consciousness and in addition significantly increased mean arterial pressure, cardiac output, and cardiac work without significantly affecting systemic vascular resistance.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
