Hemodynamic Monitoring Options in COVID-19

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA betacoronavirus, is a novel respiratory pathogen whose ominous progression has been implicated in disease that ranges from respiratory failure and acute respiratory distress syndrome (ARDS) to multi-organ dysfunction.1Guan W.J. Ni Z.Y. Hu Y. et al.Clinical characteristics of coronavirus disease 2019 in China.N Engl J Med. 2020; 382: 1708-1720Crossref PubMed Scopus (17776) Google Scholar,2Zhou F. Yu T. Du R. et al.Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study.Lancet. 2020; 395: 1054-1062Abstract Full Text Full Text PDF PubMed Scopus (16310) Google Scholar Among the most susceptible populations at risk for severe infection are patients with cardiovascular comorbidities, such as hypertension, diabetes mellitus, coronary artery disease, and cardiomyopathy, who have a higher representation among nonsurvivors.2Zhou F. Yu T. Du R. et al.Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study.Lancet. 2020; 395: 1054-1062Abstract Full Text Full Text PDF PubMed Scopus (16310) Google Scholar,3Guo T. Fan Y. Chen M. et al.Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19) [e-pub ahead of print].JAMA Cardiol. 2020 Mar 27; https://doi.org/10.1001/jamacardio.2020.1017Crossref Scopus (2450) Google Scholar Although pulmonary pathophysiologic processes undoubtedly underlie the perilous coronavirus disease 2019 (COVID-19) course, the emergence of cardiac injury later in the disease could have major implications for outcomes. Markers of myocardial injury, such as troponin and N-terminal pro-brain natriuretic peptide (NT-proBNP), have been shown to increase rapidly in nonsurvivors.2Zhou F. Yu T. Du R. et al.Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study.Lancet. 2020; 395: 1054-1062Abstract Full Text Full Text PDF PubMed Scopus (16310) Google Scholar,3Guo T. Fan Y. Chen M. et al.Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19) [e-pub ahead of print].JAMA Cardiol. 2020 Mar 27; https://doi.org/10.1001/jamacardio.2020.1017Crossref Scopus (2450) Google Scholar Although cardiovascular disease appears to predispose some patients to COVID-19–related myocardial injury, acute myopericarditis in the absence of prior disease has also been described, even without signs of interstitial pneumonia.4Inciardi R.M. Lupi L. Zaccone G. et al.Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) [e-pub ahead of print].JAMA Cardiol. 2020 Mar 27; https://doi.org/10.1001/jamacardio.2020.1096Crossref PubMed Scopus (1151) Google Scholar ARDS mechanical ventilation with high positive end-expiratory pressure (PEEP), along with the presence of intravascular thrombosis in the setting of sepsis-induced coagulopathy, could increase susceptibility to pulmonary hypertension, right heart dysfunction, and end-organ (eg, kidney) hypoperfusion.5Tang N. Bai H. Chen X. et al.Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy.J Thromb Haemost. 2020; 18: 1094-1099Crossref PubMed Scopus (2147) Google Scholar The risk of cardiovascular and renal injury in conjunction with the importance of conservative fluid management as a key tenet of ARDS treatment justifies the need for judicious monitoring of intravascular volume status in the COVID-19 cohort.6Matthay M.A. Aldrich J.M. Gotts J.E. Treatment for severe acute respiratory distress syndrome from COVID-19 [e-pub ahead of print].Lancet Respir Med. 2020 Mar 20; (pii: S2213-2600(20)30127-2)https://doi.org/10.1016/S2213-2600(20)30127-2Abstract Full Text Full Text PDF Scopus (199) Google Scholar We reflect on the clinical utility of select popular hemodynamic monitoring devices and suggest that the pulmonary artery catheter (PAC) shows empirical promise as a validated tool that maximizes monitoring capabilities and minimizes expenditure of hospital resources. It is difficult to estimate intravascular volume with current standard- of- care monitors, which could delay the timely identification of end-organ hypoperfusion and increase the risk of morbidity and mortality. Pulmonary artery catheters (PACs) can measure right atrial or ventricular pressures, pulmonary arterial pressures, and continuous mixed venous oxygen saturation (SvO2), in addition to having the capabilities to estimate systemic vascular resistance (SVR) and pulmonary vascular resistance (PVR), as well as cardiac output (CO) (Table 1).7D'Alto M. Dimopoulos K. Coghlan J.G. et al.Right heart catheterization for the diagnosis of pulmonary hypertension: Controversies and practical issues.Heart Fail Clin. 2018; 14: 467-477Abstract Full Text Full Text PDF PubMed Scopus (31) Google Scholar Together, these parameters could provide valuable information about volume status and cardiac function. Patients afflicted with pulmonary hypertension or right- heart dysfunction secondary to coagulopathy could benefit from PAC-based management of discordant right and left ventricular failure under the guidance of PVR, right ventricular ejection fraction (RVEF), and SvO2.5Tang N. Bai H. Chen X. et al.Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy.J Thromb Haemost. 2020; 18: 1094-1099Crossref PubMed Scopus (2147) Google Scholar,8Ranucci M. Which cardiac surgical patients can benefit from placement of a pulmonary artery catheter?.Crit Care. 2006; 10: S6Crossref PubMed Scopus (47) Google Scholar High PVR, low RVEF, and low SvO2, for instance, might suggest a need for inotropes. Furthermore, accurate estimations of stroke volume could also help avert pre-renal kidney injury. However, we recognize that PA catheterization is not without its limitations and risks. High intrathoracic pressures in the setting of a high PEEP strategy to improve oxygenation in ARDS could lead to overestimation of left ventricular volumes based on PA diastolic pressures. High PEEP could also theoretically increase the risk of PA perforation, one of the most feared complications of PAC use. In addition, the effectiveness of PAC-derived data in significantly altering clinical outcomes still remains equivocal.9Thakkar A.B. Desai S.P. Swan, Ganz, and their catheter: Its evolution over the past half century.Ann Intern Med. 2018; 169: 636-642Crossref PubMed Scopus (11) Google Scholar Nevertheless, we propose that the PAC maximizes resource use in the COVID-19 ICU arena by providing continuous assessments of intravascular volume and cardiac function while limiting staff exposure and personal protective equipment (PPE) usage.Table 1Technologies Available for Hemodynamic Monitoring in COVID-19 PatientsMonitoring DeviceMeasurement MethodParametersMajor AdvantagesMajor DisadvantagesPACThermodilutionMeasurements: right atrial and ventricular pressures, PAP, PCWP, SvO2 (continuously with specialized PACs)Calculations: CO, SVR, PVR, RVEFProvides numerous variables to gauge volume status and cardiac function; minimizes expenditure of hospital resources; reliable in ARDS managementHigh PEEP could lead to overestimation of LV volume by increasing PADP; invasive monitor with risk of PA perforation; equivocal effectiveness in altering clinical outcomesPiCCOTPTD, pulse wave analysisCO, SV, SVV, PPVVolumetric assessments: GEDV, EVLW, PVPIContinuous, accurate CO relative to PAC; provides volumetric measures of preload (GEDV) and pulmonary edema (EVLW, PVPI); associated with favorable ARDS outcomesInvasive monitor that requires CVC and arterial catheter*Pulse contour analysis may be less accurate in the setting of arrhythmias, valve pathology, intracardiac shunts, and extracorporeal circulation.LiDCOTranspulmonary lithium dye dilution, pulse wave analysisCO, SV, SVV, PPVContinuous, accurate CO relative to PAC; requires arterial catheter without the need for CVCUnreliable with use of muscle relaxants; not yet examined in ARDS management*Pulse contour analysis may be less accurate in the setting of arrhythmias, valve pathology, intracardiac shunts, and extracorporeal circulation.FloTracPulse wave analysisCO, SV, SVV, PPVEasy-to-use, operator-independent systemAccuracy of CO remains equivocal, especially in the setting of low SVR; SVV is poorly predictive of volume responsiveness*Pulse contour analysis may be less accurate in the setting of arrhythmias, valve pathology, intracardiac shunts, and extracorporeal circulation.NICOMThoracic bioreactanceCO, SV, SVVContinuous, accurate CO that correlates with fluid responsiveness, irrespective of hemodynamic instability or arrhythmias; noninvasive device that uses electrodesNot yet examined in ARDS managementEsophageal DopplerDoppler ultrasound in the esophagus at 45° relative to the descending aortaCO, SVAccurate assessment of CO and fluid responsiveness; provides invaluable information about preload, afterload, and contractilityExpertise required because improper positioning of the esophageal probe can underestimate COEchocardiography (transthoracic, transesophageal)2D and 3D imaging; pulsed wave DopplerCO; dynamic parameters of volume responsiveness, ie, respiratory variations in venocaval size, as well as changes in ventricular size, LVOT, VTI, and LV filling pressureDetects numerous pathophysiological states, such as wall motion abnormalities, LV diastolic dysfunction, and pericardial effusionsNo continuous monitoring; expertise requiredAbbreviations: CO, cardiac output; CVC, central venous catheter; EVLW, extravascular lung water; GEDV, global end-diastolic volume; LiDCO, lithium dilution cardiac output; LV, left ventricle; LVOT, left ventricular outflow tract; NICOM, noninvasive cardiac output monitoring; PAC, pulmonary artery catheter; PADP, pulmonary artery diastolic pressure; PAP, pulmonary arterial pressure; PCWP, pulmonary capillary wedge pressure; PEEP, positive end-expiratory pressure; PiCCO, pulse index contour cardiac output; PPV, pulse pressure variation; PVPI, pulmonary vascular permeability index; PVR, pulmonary vascular resistance; RVEF, right ventricular ejection fraction; SvO2, mixed venous oxygen saturation; SV, stroke volume; SVV, stroke volume variation; SVR, systemic vascular resistance; TPTD, transpulmonary thermodilution; VTI, velocity-time integral. Pulse contour analysis may be less accurate in the setting of arrhythmias, valve pathology, intracardiac shunts, and extracorporeal circulation. Open table in a new tab Abbreviations: CO, cardiac output; CVC, central venous catheter; EVLW, extravascular lung water; GEDV, global end-diastolic volume; LiDCO, lithium dilution cardiac output; LV, left ventricle; LVOT, left ventricular outflow tract; NICOM, noninvasive cardiac output monitoring; PAC, pulmonary artery catheter; PADP, pulmonary artery diastolic pressure; PAP, pulmonary arterial pressure; PCWP, pulmonary capillary wedge pressure; PEEP, positive end-expiratory pressure; PiCCO, pulse index contour cardiac output; PPV, pulse pressure variation; PVPI, pulmonary vascular permeability index; PVR, pulmonary vascular resistance; RVEF, right ventricular ejection fraction; SvO2, mixed venous oxygen saturation; SV, stroke volume; SVV, stroke volume variation; SVR, systemic vascular resistance; TPTD, transpulmonary thermodilution; VTI, velocity-time integral. The past 3 decades have seen the emergence of alternative devices to PACs, which are thought to provide similar hemodynamic information in a minimally invasive manner. Minimally invasive technologies can use principles of transpulmonary thermodilution or indicator dye dilution in addition to arterial waveform variation analysis from arterial catheters. These monitors gauge cardiac function through estimations of cardiac output; they can also evaluate intravascular volume status and likelihood of response to a fluid challenge through stroke- volume variation (SVV) and pulse- pressure variation (PPV).10Marik P.E. Noninvasive cardiac output monitors: A state-of the-art review.J Cardiothorac Vasc Anesth. 2013; 27: 121-134Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar Examples include the pulse index contour cardiac output (PiCCO), lithium dilution cardiac output (LiDCO), and FloTrac devices (Table 1). The PiCCO system is unique in its ability to provide volumetric assessments of preload (global end-diastolic volume) and pulmonary edema (extravascular lung water, pulmonary vascular permeability index).11De Backer D. Bakker J. Cecconi M. et al.Alternatives to the Swan-Ganz catheter.Intensive Care Med. 2018; 44: 730-741Crossref PubMed Scopus (53) Google Scholar PiCCO guidance may be associated with a shorter duration of respiratory support and faster recovery of PaO2-to-FiO2 ratios in ARDS patients, perhaps because optimization of extravascular lung water serves as a positive prognostic factor.12Yuanbo Z. Jin W. Fei S. et al.ICU management based on PiCCO parameters reduces duration of mechanical ventilation and ICU length of stay in patients with severe thoracic trauma and acute respiratory distress syndrome.Ann Intensive Care. 2016; 6: 113Crossref PubMed Scopus (13) Google Scholar,13Phillips C.R. Chesnutt M.S. Smith S.M. Extravascular lung water in sepsis-associated acute respiratory distress syndrome: Indexing with predicted body weight improves correlation with severity of illness and survival.Crit Care Med. 2008; 36: 69-73Crossref PubMed Scopus (159) Google Scholar The LiDCO system provides comparable CO measurements to PACs, but unlike the PiCCO, it has not been examined in ARDS patients managed with a high PEEP strategy; furthermore, the LiDCO is not reliable in the setting of muscle relaxation, given that quaternary ammonium ion-based agents may interfere with the lithium sensor.10Marik P.E. Noninvasive cardiac output monitors: A state-of the-art review.J Cardiothorac Vasc Anesth. 2013; 27: 121-134Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar,14Montenij L.J. de Waal E.E. Buhre W.F. Arterial waveform analysis in anesthesia and critical care.Curr Opin Anaesthesiol. 2011; 24: 651-656Crossref PubMed Scopus (65) Google Scholar The FloTrac monitor has also gained popularity as an easy-to-use, operator-independent system, but the accuracy of FloTrac-derived CO measurements remains equivocal.15Kusaka Y. Ohchi F. Minami T. Evaluation of the fourth-generation FloTrac/Vigileo system in comparison with the intermittent bolus thermodilution method in patients undergoing cardiac surgery.J Cardiothorac Vasc Anesth. 2019; 33: 953-960Abstract Full Text Full Text PDF PubMed Scopus (18) Google Scholar Furthermore, unlike the PiCCO and LiDCO monitors, the FloTrac system may not be reliable in septic patients with low SVR, nor could FloTrac-derived SVV be used for fluid optimization, as it is poorly predictive of volume responsiveness.10Marik P.E. Noninvasive cardiac output monitors: A state-of the-art review.J Cardiothorac Vasc Anesth. 2013; 27: 121-134Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar Noninvasive monitors rely on quantification of thoracic impedance variability, ultrasound imaging, and measurement of velocity-time integrals from Doppler signals to provide information about CO (Table 1). The noninvasive cardiac output monitoring (NICOM) device analyzes phase shifts in the voltage of electrical impulses passed between electrodes on either side of the body; it provides accurate CO values in mechanically ventilated patients that correlate with fluid responsiveness, irrespective of hemodynamic instability or arrhythmias, although it has yet to be studied in the context of ARDS management.10Marik P.E. Noninvasive cardiac output monitors: A state-of the-art review.J Cardiothorac Vasc Anesth. 2013; 27: 121-134Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar Ultrasound-based technologies, such as esophageal Doppler and echocardiography, have mass appeal, as they are also reliable in their real-time assessment of CO and fluid responsiveness.10Marik P.E. Noninvasive cardiac output monitors: A state-of the-art review.J Cardiothorac Vasc Anesth. 2013; 27: 121-134Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar Transthoracic and transesophageal echocardiography provide key information on ventricular function and dynamic parameters of volume responsiveness, such as respiratory variations in venocaval size, and changes in ventricular size, left ventricular outflow tract velocity-time integral, and left ventricular filling pressure.10Marik P.E. Noninvasive cardiac output monitors: A state-of the-art review.J Cardiothorac Vasc Anesth. 2013; 27: 121-134Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar,16Porter T.R. Shillcutt S.K. Adams M.S. et al.Guidelines for the use of echocardiography as a monitor for therapeutic intervention in adults: A report from the American Society of Echocardiography.J Am Soc Echocardiogr. 2015; 28: 40-56Abstract Full Text Full Text PDF PubMed Scopus (259) Google Scholar However, these monitors are limited by their intermittent nature and the need for expertise in proper ultrasound beam alignment relative to the structures of interest or direction of blood flow. In comparison to PAC use, the application of echocardiography to gauge intravascular fluid status would likely result in increased traffic of healthcare workers to and from the rooms of COVID-19 patients, along with more frequent use of PPE. The armamentarium of hemodynamic monitoring devices should be exploited to augment therapeutic tactics for conservative fluid management in a population that is vulnerable to sustaining multi-organ injury. The PAC is a promising option that maximizes monitoring capabilities while limiting exposure of healthcare workers and depletion of highly coveted PPE. The PiCCO may be a viable less-invasive alternative as it has been studied in trials of ARDS patients previously, while other monitors still have questionable accuracy and/or applicability in ARDS management with a high PEEP strategy. The COVID-19 landscape should serve as a launching pad for randomized controlled trials to evaluate whether device-driven management promotes beneficial patient outcomes. The authors would like to thank the Department of Anesthesiology faculty for their input during preparation of this letter. The authors confirm that they have no conflicts of interest to disclose.