Abstract
The frequence occurence of sensorineural hearing loss in patients with chronic renal insufficiency prompted us to study the influence of chronic renal failure upon Na+-K+-ATPase in the inner ear of guinea pigs. Na+-K+-activated ATPase was measured as the difference between total ATPase (in the presence of Na+-K+) and basal ATPase (inhibition by ouabain). A significant reduction of Na+-K+-activated ATPase (given as fraction of total ATPase) was found in the inner ear. Such inhibition could be demonstrated even 12 h after subtotal nephrectomy. An inverse correlation was found between serum creatinine levels and Na+-K+-activated ATPase. A similar inhibition of Na+-K+-activated ATPase in uremia is also found in other tissues (erythrocytes, renal tubules, intestinal mucosal cells, sarcolemma). Na+-K+-ATPase in the cochlea plays a key role in the maintenance of cochlear cationic gradients. It is suggested that inhibition of this enzyme system may contribute to the inner ear dysfunction in uremia.
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