Abstract
Numbers of Hematopoietic cell transplantation (HCT) in Europe and collaborating countries continues to rise with 48,512 HCT in 43,581 patients, comprising of 19,798 (41%) allogeneic and 28,714 (59%) autologous, reported by 700 centers in 51 countries during 2019. Main indications were myeloid malignancies 10,764 (25%), lymphoid malignancies 27,895 (64%), and nonmalignant disorders 3173 (7%). A marked growth in CAR-T cellular therapies from 151 in 2017 to 1134 patients in 2019 is observed. This year’s analyses focus on changes over 30 years. Since the first survey in 1990 where 143 centers reported 4234 HCT, the number has increased to 700 centers and 48,512 HCT. Transplants were reported in 20 countries in 1990, and 51, 30 years later. More than 800,000 HCT in 715,000 patients were reported overall. Next to the massive expansion of HCT technology, most notable developments include the success of unrelated donor and haploidentical HCT, an increase followed by decrease in the number of cord blood transplants, use of reduced intensity HCT in older patients, and the phenomenal rise in cellular therapy. This annual report of the European Society for Blood and Marrow Transplantation (EBMT) reflects current activity and highlights important trends vital for health care planning.
Highlights
The European Society for Blood and Marrow Transplantation (EBMT) published for the first time in 1990 [1] a survey describing activity in hematopoietic stem cell transplant centers in Europe
Centers report information on different types of cellular therapies qualifying as advanced therapy medicinal products (ATMP) since they result from substantial manipulations of the collected cells, whether manufactured by industry centrally, or locally by an academic institution
For allogeneic Hematopoietic cell transplantation (HCT), the numbers increased only slightly (0.4%) and the proportion of those using bone marrow decreased by 5.4%
Summary
The European Society for Blood and Marrow Transplantation (EBMT) published for the first time in 1990 [1] a survey describing activity in hematopoietic stem cell transplant centers in Europe. Since this survey was published annually and will be the 30th anniversary edition. The survey includes over 700,000 patients with over 800,000 transplants. The survey was designed in the form of a single page spreadsheet for ease of. A full list of members and their affiliations appears in the
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