HEMATOLOGICAL PROFILE OF NEWBORN CALVES AFTER THE APPLICATION OF NUCLEINATE AND SINESTROL TO DRY COWS

Abstract

The dynamics of morphological, biochemical and immunological parameters of the blood of newborn calves after the use of sodium nucleinate in combination with sinestrol 2% to pregnant cows in the period as close as possible before calving. The objects of the study were 20 clinically healthy pregnant cows of the Black-and-white, selected according to the principle of paired analogues, which were divided into 2 groups (control and experimental) of 10 animals each, and newborn calves obtained from them. On 3-9 days before calving, cows of the experimental group were administered once, intramuscularly, 0.2% aqueous solution of sodium nucleinate at a dose of 5 ml and an oil solution of sinestrol 2% (analogous to the female sex hormone estrone) at a dose of 1 ml. The cows of the control group were injected with 0.9% sodium chloride solution. On the first day of life in the blood of calves, a higher number of erythrocytes by 8.5-9.2%, hemoglobin by 20.1% was found, which indicates a more intense course of oxidation-reduction processes, and an increase in the content of leukocytes in the blood by 11.6 -29.9%, as well as the relative and absolute number of T-lymphocytes, respectively, by 6.0-6.6% and 27.1-52.7%, which indicates the development of the cellular link of the immune system. In combination with an increased content of gamma globulins in the blood and increased non-specific resistance, calves quickly adapted to environmental conditions and were resistant to non-communicable diseases.