CHANGES IN HEMATOLOGICAL INDICATORS OF NEWBORN CALVES AFTER THE USE OF SODIUM NUCLEINATE AND SYNESTROL IN DRY COWS

Abstract

The dynamics of newborn calves' morphological, biochemical, and immunological blood parameters after using sodium nucleinate in combination with 2% synestrol in dry cows, as close as possible to calving, are presented. The research involved 20 clinically healthy pregnant cows of the black-and-white breed, selected based on the principle of paired analogues. They were divided into two groups (control and experimental), with ten animals in each and the newborn calves obtained from them. Cows in the experimental group were intramuscularly administered a single dose of a 0.2% aqueous solution of sodium nucleinate at a quantity of 5 ml and a 2% oil solution of synestrol (an analogue of the female sex hormone estrone) at a dose of 1 ml, 3–9 days before calving. Cows in the control group were administered a 0.9% sodium chloride solution. On the first day of life, the blood of the calves showed a higher number of erythrocytes, by 8.5–9.2%, and haemoglobin, by 20.1%, indicating intensive oxidative-reductive processes. An increase in the blood leukocyte count by 11.6–29.9% was also observed, as well as a relative and absolute increase in T-lymphocytes by 6.0–6.6 and 27.1–52.7%, respectively, indicating the development of the cellular component of the immune system. Along with the increased gamma-globulin content in the blood and enhanced nonspecific resistance, the calves adapted faster to external environmental conditions and were resistant to non-infectious diseases.