HEMATOLOGICAL AND BIOCHEMICAL CHANGES IN FEMALE DIABETES MELLITUS TYPE-2 PATIENTS ATTENDING TERTIARY CARE HOSPITAL QUETTA

Abstract

Diabetes mellitus is notoriously known around the globe for its pathological problems and it is mostly linked with metabolic, cellular, and blood disorders. In previous studies, the biochemical and hematological anomalies have been associated with type 2 diabetes disorder. In studying this, we compared and analyzed the hematological and biochemical parameters between non-diabetic and diabetic patients from Quetta, Pakistan, and highlighted the anomalies. The results of this study discovered significant anomalies in the biochemical and hematological parameters of diabetic type 2 patients compared with non-diabetic patients. In this study, we conducted a comparative cross-sectional analysis on 100 volunteers among them 50 volunteers were diabetic type 2 patients and the remaining 50 were taken as control these volunteers were selected by applying a systematic random sampling technique. For hematological andbiochemical analysis 5ml of blood from the patients and control group was drawn and subsequently analyzed using an automated cell counter. That was analyzed by using SPSS 22 version. In this study, the majority of subjects in both groups were females. The results of this study displayed that the level of MCV, PVC, RBCs, and hemoglobin was significantly lower compared to diabetic-free individuals. Whereas; mean WBCs and MCHC were highly significant in diabetics patients than the diabetic-free individuals. We did not observe any difference in the level of MCH between both groups. In the case of biochemical parameters comparison, the mean of LDL, TC, creatinine, and urea was higher in the diabetic group as compared to the control group and the value of HDL was lower in the diabetic group.