Effect of hormones on osteoporosis in diabetic and non-diabetic elderly patients

Abstract

Objective To study the effect of hormone to bone mineral density (T-score) between diabetic and non-diabetic elderly patients. Methods Took the lumbar and femoral bone mineral density (T-score) low value and sex, age, height, weight and a variety of hormone between diabetes group and non-diabetes in partial correlation analysis. Compared the hormones in the diabetes group complicated with osteopenia or osteoporosis (DO group), simple diabetes group (S-DM group) and simple osteopenia or osteoporosis group (S-OP group). Described measurement data in median (M), quarterback data range (P25-P75), compared in pairs with Mann-Whitney test, multiple factors analysis used partial correlation analysis. Results Partial correlation analysis: T-score was related to weight in diabetes group (r=0.310, P=0.002), and it was all related to sex, height and weight in non-diabetes group (r=-0.282, 0.279, 0.415, P<0.001, <0.001, <0.001). Body weight was related with the T-score in DO group and S-OP group (r=0.394, 0.321, P=0.003, <0.001). In terms of hormone, the T-score of the diabetic group was related to the C peptide (r=0.259, P=0.012), and non-diabetes group was associated with estradiol (E2), growth hormone (GH), C peptide (C-P) (r=0.184,-0.191, 0.166, P=0.019, 0.015, 0.035). DO group was associated with Thyroid-stimulating hormone (sTSH) (r=0.269, P=0.047), S-OP group correlates with the E2 (r=0.198, P=0.032). Compared the DO group with S-DM group or S-OP group: DO group compared with S-DM group, weight, C-P were statistically significant (Z=-2.375,-3.308, P=0.020, 0.001), DO group compared with S-OP group, sex, weight, GH, C-P were statistically significant (Z=-2.184,-2.166,-3.149,-2.109, P=0.029, 0.030, 0.002, 0.035). Conclusions Bone mineral density were related to weight in diabetic and non-diabetic patients, but it was also related to sex in non-diabetic patients. Bone mineral density was associated with the C peptide in diabetic patients, bone mineral density was related with E2, GH, C-P in non-diabetic patients. C-P may have effect on the bone mineral density of diabetic osteoporosis patients. Compared with simple osteopenia or osteoporosis without complicated with diabetes, the effect of GH, C-P to the bone mineral density in DO patients may be more obvious. Key words: Diabetic osteoporosis; Bone mineral density; Hormone; Partial correlation