Contrast research of vascular endothelial growth factor and myeloperoxidase between diabetic and non-diabetic patients with maintenance hemodialysis

Abstract

Objective To observe the difference of vascular endothelial growth factor (VEGF) and myeloperoxidase (MPO) between diabetic and non-diabetic patients with maintenance hemodialysis (MHD), and to explore whether it was associated with duration of hemodialysis. Methods A total of 120 patients with MHD were divided into diabetic group (40 cases) and non-diabetic group (80 cases) according to the primary disease. The blood samples from the patients before dialysis were selected to test the serum VEGF and plasma MPO and other indicators. The blood samples from April 2012 to March 2013 were labeled diabetic group 1(40 cases) and non-diabetic group 1 (80 cases). The blood samples from April 2013 to March 2014 were labeled diabetic group 2 (40 cases) and non-diabetic group 2 (80 cases). Results The serum VEGF and plasma MPO levels were (74.63±47.43) ng/L, (300.63±235.37) μg/L in diabetic group 1, and(63.69±43.23) ng/L, (275.35±216.32) μg/L in non-diabetic group 1, and there were significant differences between two groups (P<0.05). The serum VEGF and plasma MPO levels were (83.32±40.38) ng/L, (414.12±265.52) μg/L in diabetic group 2, and (70.89±39.74) ng/L, (289.45±202.85) μg/L in non-diabetic group 2, and there were significant differences between two groups (P<0.05). The correlation analysis showed that VEGF was positively correlated with MPO in diabetic group 1 and diabetic group 2 (r=0.632 and 0.763, P<0.05), and VEGF was positively correlated with MPO in non-diabetic group 1 and non-diabetic group 2 (r=0.610 and 0.713, P<0.05). Conclusions Compared with those in non-diabetic MHD patients, VEGF and MPO levels are significantly higher in diabetic MHD patients. In non-diabetic MHD patients and diabetic MHD patients, VEGF and MPO levels will rise gradually with duration of hemodialysis. The expressions of VEGF and MPO are associated with each other. Key words: Hemodialysis; Endothelial growth factor; Myeloperoxidase