Abstract
BackgroundThe aim of this study was to evaluate the association between hematinic deficiencies and recurrent aphthous stomatitis (RAS).Material and Methods517 RAS patients and 187 healthy controls were enrolled in the present study. Hematinic deficiencies, including serum ferritin, folic acid, and vitamin B12 deficiencies were assessed for each participant. Gender and age were taken into account and the collected data were statistically analysed.ResultsCompared with the healthy controls, a significantly higher overall frequency of hematinic deficiencies was found in RAS patients (p<0.001). When gender and age were taken into account, significant differences in hematinic deficiencies were observed among RAS patients. Serum ferritin deficiency was much more common in young and middle-aged female RAS patients (age<60). Serum folate deficiency and serum vitamin B12 deficiency were both much more common in the young adult group of male RAS patients (21–40 years of age). Logistic regression analysis revealed that both gender and age have significant correlation with the presence of hematinic deficiencies in the RAS patients.ConclusionsSignificant variations in hematinic deficiencies were demonstrated in RAS patients across different genders and age groups. We suggest that further studies on the hematinic deficiencies of RAS patients should take into account the gender and age of participants. Key words:Recurrent aphthous stomatitis, hematinic deficiencies, gender, age.
Highlights
Recurrent aphthous stomatitis (RAS), characterized by recurrent ulcerations limited to the oral mucosa, is one of the most common oral mucosal disorders, affecting approximately 20% of the general population and reaching as high as 60% in specific areas or populations [13]
When gender and age were taken into account, significant differences in hematinic deficiencies were observed among recurrent aphthous stomatitis (RAS) patients
Considering age only, significant differences in hematinic deficiencies were revealed among age subgroups of the RAS patients, except the serum vitamin B12 deficiency (Table 1)
Summary
Recurrent aphthous stomatitis (RAS), characterized by recurrent ulcerations limited to the oral mucosa, is one of the most common oral mucosal disorders, affecting approximately 20% of the general population and reaching as high as 60% in specific areas or populations [13]. The conclusions of existing studies are still inconsistent, and many contradictory results have been reported [2,7,8,9,10,11,12,13,14,15,16,17] Possible reasons for this include differences in race/ethnicity, geographic, and dietary characteristics among RAS patients [1,2,6]. Further studies are necessary to determine whether the hematinic deficiencies of RAS patients vary significantly in different gender and age groups. When gender and age were taken into account, significant differences in hematinic deficiencies were observed among RAS patients. Conclusions: Significant variations in hematinic deficiencies were demonstrated in RAS patients across different genders and age groups. We suggest that further studies on the hematinic deficiencies of RAS patients should take into account the gender and age of participants
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