Helicobacter pylori Infection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis.

Jun-Zhen Li,Tao Yu,Jie-Yao Li,Qi-Kui Chen,Can-Ze Huang,Di Cheng,Ji-Hao Xu,Ting-Feng Wu

doi:10.1155/2017/5715403

Abstract

Background Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed. Published studies reporting H. pylori infection in both DM and non-DM individuals were recruited. Results 79 studies with 57,397 individuals were included in this meta-analysis. The prevalence of H. pylori infection in DM group (54.9%) was significantly higher than that (47.5%) in non-DM group (OR = 1.69, P < 0.001). The difference was significant in comparison between type 2 DM group and non-DM group (OR = 2.05), but not in that between type 1 DM group and non-DM group (OR = 1.23, 95% CI: 0.77–1.96, P = 0.38). Conclusion Our meta-analysis suggested that there is significantly higher prevalence of H. pylori infection in DM patients as compared to non-DM individuals. And the difference is associated with type 2 DM but not type 1 DM.

Highlights

Helicobacter pylori (H. pylori) is a gram-negative spiral bacterium, colonized in the stomach
Guo et al demonstrated that diabetes was a risk factor for H. pylori infection [23]
Several metaanalyses aiming to investigate the association between H. pylori infection and diabetes mellitus (DM) have been carried out

Summary

Introduction

Helicobacter pylori (H. pylori) is a gram-negative spiral bacterium, colonized in the stomach. Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. There are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed. Published studies reporting H. pylori infection in both DM and non-DM individuals were recruited. 79 studies with 57,397 individuals were included in this meta-analysis. The prevalence of H. pylori infection in DM group (54.9%) was significantly higher than that (47.5%) in non-DM group (OR = 1.69, P < 0 001). Our meta-analysis suggested that there is significantly higher prevalence of H. pylori infection in DM patients as compared to non-DM individuals. The difference is associated with type 2 DM but not type 1 DM

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Conclusion