Abstract
Background Helicobacter pylori is a pathogenic bacterium that has been linked to many disorders such as cardiovascular diseases, diabetes mellitus, and dyslipidemia. However, whether it is associated with insulin resistance still needs to be evaluated. In this work we aimed to delineate the possible relation of H. pylori infection with insulin resistance in nonobese nondiabetic patients. Patients and methods The study was carried out on 80 individuals who were divided into two groups. Forty patients were diagnosed to have H. pylori and 40 healthy volunteers formed the control group. All were subjected to history taking, clinical examination, routine laboratory investigations, evaluation of H. pylori immunoglobulin G level, and assessment of fasting blood glucose and fasting insulin level to calculate homeostasis model assessment of insulin resistance. Results There was a significant increase in C-reactive protein in H. pylori-positive patients when compared with H. pylori-negative controls. Also a significant positive correlation was found between homeostasis model assessment of insulin resistance and each of fasting blood glucose, fasting insulin, and C-reactive protein in both groups. Conclusion H. pylori infection was strongly associated with insulin resistance in nonobese, nondiabetic patients.
Published Version
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