Abstract
Letters4 May 2004Helicobacter pylori and Idiopathic Thrombocytopenic PurpuraFrancesco Franceschi, MD, Nicholas Christodoulides, PhD, Michael H. Kroll, MD, and Robert M. Genta, MDFrancesco Franceschi, MDFrom Catholic University of Rome, 00168 Rome, Italy; and Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030.Search for more papers by this author, Nicholas Christodoulides, PhDFrom Catholic University of Rome, 00168 Rome, Italy; and Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030.Search for more papers by this author, Michael H. Kroll, MDFrom Catholic University of Rome, 00168 Rome, Italy; and Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030.Search for more papers by this author, and Robert M. Genta, MDFrom Catholic University of Rome, 00168 Rome, Italy; and Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-9-200405040-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Idiopathic thrombocytopenic purpura (ITP) is a hematologic disorder characterized by sensitization of platelets by autoantibodies leading to platelet destruction (1-4). Although its cause remains unclear, ITP is associated with several diseases, including infections (5-8).Helicobacter pylori, a gram-negative bacterium, is a frequent cause of upper gastrointestinal tract infection (9). Of interest, the presence of the cytotoxin-associated gene A (CagA), an important determinant of pathogenicity, is associated with greater gastric mucosal immune responses (9).Objective: In a previous study, we described increasing platelet counts in patients with ITP 4 months after eradication of CagA-positive H. pylori infection ...
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