Abstract
RECENT reports indicate1,2 that cultured skin fibroblasts from subjects with Werner's syndrome, a hereditary disease of premature ageing3, have an increased proportion of heat-labile glucose-6 phosphate dehydrogenase (G-6PD) compared with normal cells undergoing ageing in vitro1,2,4. Additionally, two HL-A antigens show profoundly altered reactivities with specific antisera2, which in total demonstrates that three diverse gene products are markedly abnormal in Werner's fibroblasts. The purpose of our study was to document further this phenomenon in Werner's cells. We now report a high heat-labile fraction of 6-phosphogluconate dehydrogenase (6-PGD), an enzyme involved in the hexose monophosphate shunt, and hypoxanthine–guanine phosphoribosyltransferase (HGPRT), an enzyme concerned with purine metabolism.
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