Abstract
The concept of translational medicine involves promoting the rapid transfer of observations made in the areas of research and pathophysiological understanding to the medical practice. This approach is a reality in major Brazilian research centers which link academia and clinical practice. Heart failure (HF) is a complex syndrome that can manifest itself as heart failure with preserved ejection fraction (HFpEF), acute heart failure, or chronic heart failure with reduced ejection fraction (HFrEF). Here, we will cover the type of HF [...]
Highlights
The concept of translational medicine involves promoting the rapid transfer of observations made in the areas of research and pathophysiological understanding to the medical practice
Heart failure (HF) is a complex syndrome that can manifest itself as heart failure with preserved ejection fraction (HFpEF), acute heart failure, or chronic heart failure with reduced ejection fraction (HFrEF)
We will cover the type of HF whose pathophysiology is understood the best and has disease-modifying treatments: HFrEF
Summary
The concept of translational medicine involves promoting the rapid transfer of observations made in the areas of research and pathophysiological understanding to the medical practice. In 1986, Cohn et al published one of the first major studies that laid the foundation for HF specialists: “Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure.7” The use of hydralazine in association with isosorbide dinitrate demonstrated that peripheral vasoconstriction contributed to the worsening of HF symptoms and favored the deterioration of left ventricular function and sudden death.
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