Abstract
Objective The study goal was to compare the severity of hearing loss with semicircular canal injury in the presence of otitis media (OM) due to an exotoxin A–producing strain of Pseudomonas aeruginosa (PA+) and an exotoxin A–deficient daughter strain (PA−). Methods PA+ or PA− was injected bilaterally into guinea pig ears. Three days later, unilateral lateral semicircular canal transection was performed. Hearing was tested before and after transection. Results PA OM was induced in all injected ears. Significant elevation of click and 12-kHz thresholds ( P < 0.0001) were encountered in PA+-infected ears. No significant threshold elevations were encountered in PA−-infected ears. Conclusion Hearing loss resulting from canal injury in the presence of Pseudomonas OM may be mediated by exotoxin A. Significance Treatment to neutralize the effects of exotoxin A may minimize the risk of hearing loss with canal fistula in chronic OM.
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