Abstract

Guinea pigs were surgically prepared with permanent monopolar recording electrodes and bipolar lesion electrodes placed in the 8th nerve cochlear-nucleus region. Continuous-trace absolute-threshold recordings (visual-detection level) for 1, 50, 100, and 1000 clicks/second were made over 3-min measurement periods by means of a motor-driven recording attenuator. Neural equilibration at suprathreshold levels was evaluated in terms of evoked-potential amplitudes. Following subtotal electrolytic lesions to the nerve, threshold and amplitude changes were monitored regularly over a 13-week period. Parallel data were collected from additional guinea pigs trained to track absolute thresholds to discrete white-noise stimuli by means of an avoidance-conditioning procedure. Changes in auditory function are interpreted in terms of reversible and nonreversible neural damage. [Work supported in part by National Institute of Neurological Diseases and Blindness.]

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