Abstract
Background:Hypercholesterolemia is a modifiable risk factor in atherosclerosis with a complex association with inflammation.Objective:In the present study, the association between low-density lipoprotein cholesterol (LDL-C) and interleukin 17A (IL-17A), as an inflammatory cytokine, was investigated. In addition to IL-17A, serum levels of interleukin 23 (IL-23) and transforming growth factor β (TGF-β), as effective cytokines in T helper 17 cell (Th17) development, were also determined.Method:Cytokine levels were measured using enzyme-linked immunosorbent assay (ELISA) in healthy subjects with LDL-C<130 versus LDL-C=>130 mg/dL.Results:Although IL-17A is an inflammatory cytokine and a positive association between its levels and LDL-C is expected, the data obtained in this study provide support for a reverse association (p<0.05).Conclusion:Inflammation plays a major role in atherosclerosis development; however, various inflammatory components involved in atherosclerosis assert their own unique association with hypercholesterolemia.
Highlights
Atherosclerosis is one of the most common causes of cardiovascular disease
The aim of this study was to investigate any possible association between serum levels of transforming growth factor β (TGF-β), interleukin 23 (IL-23), interleukin 17A (IL-17A) and low-density lipoprotein cholesterol (LDL-C) in healthy people with increased levels of LDLC
This study was conducted to investigate any association between IL-17A, IL-23, TGF-β and LDL-C in people with LDL-C higher than normal range (130 mg/dL)
Summary
Atherosclerosis is one of the most common causes of cardiovascular disease. It begins early in life, making primary prevention efforts necessary from childhood [1]. There is a complex association between lipid metabolism, atherosclerosis and inflammation [6]. Among inflammatory mediators, raised plasma levels of C-Reactive Protein (CRP) is associated with increased risk of coronary heart diseases [10]. IL-17A is signature cytokine of Th17 cells associated with inflammatory and autoimmune diseases [12], and its association with atherosclerosis is still controversial. The aim of this study was to investigate any possible association between serum levels of TGF-β, IL-23, IL-17A and LDL-C in healthy people with increased levels of LDLC. Hypercholesterolemia is a modifiable risk factor in atherosclerosis with a complex association with inflammation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
