Abstract
Objectives: Prospectively assess the healing mechanism of human traumatic tympanic membrane perforation (TMP). Methods: The spontaneous healing process of 20 patients with traumatic TMPs was photographed and analyzed. Results: Of the 20 patients with traumatic TMPS, 16 suffered dry perforations and four had wet perforations. Of the 16 dry perforations, in 13 patients, centripetal migrating epithelium was the first layer to close the perforation, followed by the fibrous layer. In 3 of 16 dry perforations, outward epithelial migration was observed on the side of perforation edge. Of the four wet perforations, granulation tissue formation of a fibrous layer was the first layer to close the perforation, after which it was covered by migrating epithelium. Additionally, within 1 week after injury, healing of dry perforations was slow, the estimated percentage not exceeding 30%, while that of wet perforations was significantly faster; the estimated percentages were 60-95%. Conclusions: The healing mechanism of human traumatic TMPs may be related to the eardrum condition. Centripetal migrating epithelium from the proliferation center plays a crucial role in healing of dry perforations. In contrast, granulation tissue formation from the connective tissue layer plays an important role in healing of wet perforations.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call