Abstract

Background: Many studies have confirmed headache as one of the most common COVID-19-related neurological symptoms. There are some reports concerning migraine attacks during SARS-CoV-2 infection with an unusual course of migraine attack. Our aim was to recognize and characterize accurately the features of headaches accompanying this disease. Methods: Research based on questionnaire study gathered 100 randomly chosen medical healthcare employees who experienced symptoms associated with COVID-19 disease, 96 with confirmed COVID-19 (positive SARS-CoV-2 PCR laboratory test or positive rapid COVID-19 antigen test). Conclusion: Headaches reported in the study did not fulfill criteria for migraine with/without aura, tension-type headache according to ICHD-3.

Highlights

  • The first cases of unknown severe pneumonia were observed in Wuhan, the capital of Hubei Province, China, in December 2019

  • Many neurological manifestations have been reported in the literature associated with COVID-19, which we can classify into central nervous system (CNS)-related manifestations including headache, dizziness, impaired consciousness, acute cerebrovascular disease, and epilepsy, or peripheral nervous system (PNS) related manifestations such as hyposmia/anosmia, hypogeusia/ageusia, muscle pain, and Guillain–Barre syndrome [4]

  • We found that migraine visual aura preceding headache was noticed in 6/83 (7%) patients, unilateral headache character occurred in 6%, and the pulsating headache type without unilateral character was in 17% of participants

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Summary

Introduction

The first cases of unknown severe pneumonia were observed in Wuhan, the capital of Hubei Province, China, in December 2019. It has been proven indubitably that coronaviruses possess neurotropic and neuroinvasive properties in various hosts including humans, rats, pigs, rodents and fowl [2]. Many neurological manifestations have been reported in the literature associated with COVID-19, which we can classify into central nervous system (CNS)-related manifestations including headache, dizziness, impaired consciousness, acute cerebrovascular disease, and epilepsy, or peripheral nervous system (PNS) related manifestations such as hyposmia/anosmia, hypogeusia/ageusia, muscle pain, and Guillain–Barre syndrome [4]. Many studies have confirmed headache as one of the most common COVID19-related neurological symptoms. Methods: Research based on questionnaire study gathered 100 randomly chosen medical healthcare employees who experienced symptoms associated with COVID-19 disease, 96 with confirmed COVID-19 (positive SARS-CoV-2 PCR laboratory test or positive rapid COVID-19 antigen test). Conclusion: Headaches reported in the study did not fulfill criteria for migraine with/without aura, tension-type headache according to ICHD-3.

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