Abstract
A 72-year-old woman with myocardial infarction and cerebral infarction was studied because of her markedly increased concentration of plasma high-density lipoprotein (HDL). The concentration of HDL-cholesterol was 152mg per 100ml. The cholesterol and phospholipid levels in the HDL2 fraction were greatly elevated. In contrast, the activity of post-heparin plasma hepatic triglyceride lipase (H-TGL) was only 18 per cent of normal. The daughter and the granddaughter of the proband showed a similar increase in plasma HDL2 level and also a decrease in H-TGL activity, 12.5 and 22 per cent of normal respectively. In this family, there were no causal factors that would account for the increased HDL level nor for the decreased activity of H-TGL. A physiological role for H-TGL remains obscure, a further examination of lipoprotein metabolism and abnormality in H-TGL in these patients may provide important information concerning the physiological role for this enzyme and for the relationship between plasma HDL and the progression of atherosclerosis.
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