Abstract
Hepatitis C virus (HCV) is a global population problem due to its high prevalence, usually late diagnosis, the difficulties of treatment. In the prognosis of patients with HCV not only hepatic, but increasingly frequent of extrahepatic HCV manifestations, such as mixed cryoglobulinemia (CG), are important. Mixed CG is currently considered as a B-cell benign lymphoproliferative disorders. The role of HCV virus in the pathogenesis of lymphoproliferative diseases is confirmed by a large number of epidemiological studies, as well as by the effectiveness of antiviral therapy in patients with non-Hodgkin's lymphoma (NHL). The purpose of the review was to provide an overview of recent literature data and the meta-analysis of epidemiological data explaining the role of HCV in the development of NHL. The review also discusses the treatment for HCV-associated NHL by antiviral therapy or other therapeutic options, such as chemotherapy.
Highlights
Hepatitis C virus (HCV) is a global population problem due to its high prevalence, usually late diagnosis, the difficulties of treatment
The role of HCV virus in the pathogenesis of lymphoproliferative diseases is confirmed by a large number of epidemiological studies, as well as by the effectiveness of antiviral therapy in patients with non-Hodgkin’s lymphoma (NHL)
The purpose of the review was to provide an overview of recent literature data and the meta-analysis of epidemiological data explaining the role of HCV in the development of NHL
Summary
7±3,16 года [42], что совпадает с данными литературы: на основании ретроспективного анализа установлено, что период экспозиции с момента диагностики HCV до развития лимфопролиферативного заболевания составляет 10– 20 лет [4, 11, 15, 27, 32]. При цитологическом исследовании биоптата лимфатического узла больных с HCV-ассоциированной В-НХЛ обращают на себя внимание более выраженная базофилия цитоплазмы опухолевых клеток, полиморфизм и дольчатость ядер, четкая очерченность нуклеол [12, 27, 43,44,45]. Частота выявления РНК HCV в лимфатических узлах больных с В-НХЛ, по результатам разных исследований, колеблется в широких пределах. По данным итальянских авторов, РНК HCV в лимфатических узлах обнаруживается у 24% больных В-НХЛ, по данным японских авторов – у всех 100% [15, 30, 37, 47]. Hermine и соавт. [47] опубликовали данные о результатах лечения 9 больных c лимфо-
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