Abstract
Diabetic peripheral neuropathy (DPN) is one of the most common long-term microvascular complications of diabetes. This study was undertaken to investigate the association of HbA1c variability with diabetic peripheral neuropathy (sensory and motor) in patients with type-2 diabetes. In this cross-sectional study, a total of 150 type-2 diabetic patients were screened for DPN and undergone quarterly HbA1c measurements during the year preceding enrolment were recruited. DPN was confirmed in patients displaying both clinical manifestations of neuropathy and neurological abnormalities assessment. Among the recruited patients, 24% (n = 36) were found to have DPN, and these patients also presented with a higher HbA1c as compared to the patients without DPN (p<0.05). In addition, the advanced age and longer duration of diabetes were important and significant (p<0.05) risk factors for peripheral neuropathy. Overall study suggests that increased HbA1c level is strongly associated with DPN (sensory and motor) in type-2 diabetic patients and could be considered as a potent indicator for DPN in the recruited patients. J. Bio-Sci. 29(1): 93-100, 2021 (June)
Highlights
Diabetes is the fastest growing non-communicable health problem globally in 21st century
The present study investigated the association of HbA1c with Diabetic peripheral neuropathy (DPN) in type-2 diabetic patients
UK studies have indicated a lower incidence of DPN in type-2 South Asian diabetic patients relative to European patients living in the UK, even after age adjustment (Abbott et al 2005, Chaturvedi et al 2002)
Summary
Diabetes is the fastest growing non-communicable health problem globally in 21st century. It was estimated that nearly 463 million adult aged 20-79 were suffering from diabetes globally and 8.4 million in Bangladesh in the year 2019. This figure is expected to reach 700 million by 2045 globally and 15 million in Bangladesh (IDF Diabetes Atlas 2019). The prevalence of diabetic complications would rise with increasing rate of diabetes (Thibault et al 2016). 4.2 million people died from diabetes and its complications world-wide in the year 2019 (IDF Diabetes Atlas 2019). Neuropathy is the most common of all complications of diabetes estimated around 60% (Martin et al 2014). One of the most frequent microvascular complications of diabetes is related with foot ulceration, amputation and significant quality of life (Carrington et al 2002, Boulton et al 2004)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
