A Study on Peripheral Neuropathy and Its Related Risk Factors Associated With hba1c Levels

Ma Hossain,Sms Islam,Mk Sarkar,I Mahbub

doi:10.3329/jbs.v29i2.54961

Abstract

Diabetic peripheral neuropathy (DPN) patients frequently feel persistent pain, which is described as painful diabetic peripheral neuropathy (PDPN), which begins in both feet and frequently spreads to the calves, fingers, and hands. PDPN not only causes pain, but also affects patients' sleep, emotions, mental state, and everyday activities, resulting in a low quality of life and a significant financial burden. The goal of this study was to monitor if there was a link between the prevalence, pattern, and related risk factors of diabetic peripheral neuropathy and hemoglobin A1C (HbA1c) levels. In this crosssectional study, 150 type-2 diabetic patients were screened for DPN with PDPN and their HbA1c level was measured in every three months. DPN, PDPN and non-painful DPN were confirmed in patients displaying both clinical manifestations of neuropathy and neurological abnormalities assessment. DPN was detected in 24% (n = 36), while PDPN was found at 15% (n = 23) of the total patients. The prevalence of PDPN is 63.88% (n = 23) and non-painful DPN is 36.11% (n = 13) of total DPN (n = 36). Out of total PDPN (n = 23), the prevalence of symmetrical pain is 65% (n = 15), asymmetrical 35% (n = 8), sensory 26% (n = 6), motor 13% (n = 3), mixed (sensorimotor) 61% (n = 14), lower limb involvement 48% (n = 11), upper limb13% (n = 3) and both limb 39% (n = 9). In comparison to patients without DPN, both PDPN and non-painful DPN, patients had greater HbA1c levels (p<0.05). Furthermore, advanced age and longer diabetes duration were considerable and significant (p<0.05) risk factors for DPN with PDPN and non-painful DPN respectively. Overall, the findings imply that elevated HbA1c levels are closely linked to DPN, PDPN and non-painful DPN in type-2 diabetic patients and that HbA1c might be used as a predictive marker for DPN with PDPN and non-painful DPN in the patients studied. J. Bio-Sci. 29(2): 123-138, 2021 (December)

Highlights

Diabetes mellitus (DM) is a kind of hyperglycemia that is linked to metabolic syndrome, a condition marked by insulin resistance (Gallagher et al 2011)
Painful diabetic neuropathy (PDN), as well as bothersome autonomic characteristics such as orthostatic hypotension, are clinical symptoms of Diabetic peripheral neuropathy (DPN) (Boulton et al 2005), autonomic neuropathy of the heart (Vinik and Ziegler 2007), noncardiac autonomic neuropathy causes a variety of different diseases (Vinik and Ziegler 2007), and a lack of trauma sensitivity (Boulton et al 2005, Narres et al 2017)
We investigated the association of hemoglobin A1C (HbA1c) with the prevalence of different characteristics of DPN in type-2 diabetic patients

Summary

Introduction

Diabetes mellitus (DM) is a kind of hyperglycemia that is linked to metabolic syndrome, a condition marked by insulin resistance (Gallagher et al 2011). Diabetes mellitus has reached epidemic proportions worldwide, with 700 million people expected to have the disease by 2045 (IDF Atlas 2019). Diabetes-related deaths are expected to kill almost four million persons aged 20 to 79 in 2019. Long-term diabetes damages several organs, resulting in serious retinopathy, nephropathy, and neuropathy problems (Gionfriddo et al 2014). Painful diabetic neuropathy (PDN), as well as bothersome autonomic characteristics such as orthostatic hypotension, are clinical symptoms of DPN (Boulton et al 2005), autonomic neuropathy of the heart (a clinical condition which can result in sudden death) (Vinik and Ziegler 2007), noncardiac autonomic neuropathy causes a variety of different diseases (such as gastro-paresis and erectile dysfunction) (Vinik and Ziegler 2007), and a lack of trauma sensitivity (which can result in ulceration, infections, and lower extremity amputations) (Boulton et al 2005, Narres et al 2017)

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