Abstract
A new abnormal hemoglobin was found in a diabetic Maltese woman by citrate agar electrophoresis. This variant was undetectable by isoelectric focusing. No hematological abnormalities were observed. The structural analysis included isolation of the abnormal β chain, high pressure liquid chromatography of the corresponding tryptic peptides and then microsequencing of the abnormal T 1. These procedures revealed a double abnormality: the presence of a methionyl residue extending the NH 2 terminus and a histidine to proline substitution in position NA 2.
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