Abstract
Aim of this survey is to report the most recent views about Hashimoto’s thyroiditis (HT) natural history according to the different presentations. In children presenting with either euthyroidism or subclinical hypothyroidism HT spontaneous course is frequently characterized by a trend towards deterioration of thyroid function, whereas in those presenting with overt hyperthyroidism a definitive resolution of hyperthyroid phase is to be expected. Another possible even though unusual outcome of HT is the conversion to Graves’ disease.
Highlights
Autoimmune thyroid disease (AITD) manifests itself in various clinical forms such as classical Hashimoto' s thyroiditis (HT) and Graves' disease (GD)
GD and HT have different phenotypes and the mechanisms leading to their dichotomy are unknown, they are generally believed to share a number of common etiological factors
Aim of the present review is to report the most recent views about HT natural history according to the different presentations
Summary
Autoimmune thyroid disease (AITD) manifests itself in various clinical forms such as classical Hashimoto' s thyroiditis (HT) and Graves' disease (GD). Thyroid function at presentation may significantly vary in the different pediatric reports [12,13,14,15,16], ranging from euthyroidism to overt hypothyroidism or, occasionally, hyperthyroidism [12].
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