Hashimoto’s encephalopathy presenting with acute confusional state in a patient with hypothyroidism

Abstract

Hashimoto’s encephalopathy is a neurological disorder of unknown etiology associated with thyroid autoimmunity. The disease may present as two types, a sudden vasculitic type or a progressive subacute type associated with cognitive dysfunction, confusion and memory loss.We report a case of a 6year old previously healthy Egyptian female , who developed a subacute onset of declining upper brain function. Serologic studies demonstrated high levels of antithyroid antibodies. Electroencephalographic and magnetic resonance image findings were consistent with Hashimoto’s encephalopathy.Hashimoto’s encephalopathy is a diagnosis of exclusion. This unusual disorder is often underrecognized because of multiple neurocognitive manifestations; therefore, it is important to be aware of the clinical manifestations to make a correct diagnosis.