Haptoglobin Polymorphism in Breast Cancer

Abstract

Objects: To investigate the association between haptoglobin genotypic polymorphism and development of breast cancer, we evaluated cases diagnosed with breast cancer in our hospital and healthy individuals who were selected at random. Methods: Haptoglobin genotypes were analyzed with polymerase chain reaction method in 138 normal controls and 87 patients with non-familiar breast cancer. Results: The haptoglobin genotypes of breast cancer patients were as the follows: Hp^1/Hp^1, 10.3%; Hp^2/Hp^1, 42.5% and Hp^2/Hp^2, 42.5%, Hp^1/Hp(superscript del): 3.45% and Hp Hp^2/Hp(superscript del) 1.15%. The allele frequencies of Hp(superscript del), Hp^1 and Hp^2 were 2.3%, 33.3% and 64.4%, respectively. The frequency of Hp genotype was the same as that of the control individuals. The frequency of Hp allele was also not different from that of healthy individuals. Fifty breast cancer cases had pathological report for further analysis of the association between the parameters and Hp genotype, and it did not show any significant difference. The clinical courses were also analyzed and showed no difference in survival in each Hp genotype. Conclusions: Results of this study demonstrate that haptoglobin genotype polymorphism does not play an important role in carcinogenesis in breast cancer.