Abstract
BackgroundType 2 diabetes mellitus (T2DM) is an inflammatory condition associated to obesity and increased oxidative stress. Haptoglobin (Hp) is an acute phase reactant that scavenges extracorpuscular hemoglobin from circulation and prevents heme-iron oxidative damage. ObjectiveTo assess the association between Hp levels and Hp1–Hp2 gene polymorphism and clinical and laboratory parameters in patients with T2DM. MethodsThe study sample consisted of 102 T2DM patients and 62 controls. Hp plasma levels were measured using an ELISA assay, and Hp genotyping was performed using a specific two-step allelic polymerase chain reaction. ResultsHp levels were higher in T2DM patients as compared to controls (p=0.005). T2DM patients with high blood pressure had higher Hp levels than patients without this comorbidity (p=0.021). Obese T2DM patients had higher Hp levels as compared to obese controls (p=0.009) and to non-obese T2DM patients (p=0.003). The Hp1–Hp1 genotype was showed to be associated to T2DM according to additive (OR=3.038, 95% CI 1.127–8.192; p=0.036) and dominant model (OR=0.320, 95% CI 0.118–0.839; p=0.010), but Hp2 allele carriers contributed with higher Hp levels in T2DM as compared to controls. Waist circumference (p=0.002), BMI (p=0.001), and IL-6 (p=0.012), and hs-CRP (p=0.001) levels positively correlated with Hp levels in the T2DM group. ConclusionThese results suggest that Hp levels are influenced by Hp1–Hp2 polymorphism, obesity, inflammatory status, and high blood pressure in T2DM.
Published Version
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