Abstract
Optical coherence tomography (OCT) is a label-free, high-resolution, three-dimensional imaging technique in medical research and clinical diagnosis. Handheld OCT with a miniaturized probe instead of a fixed stage improves the flexibility of OCT imaging. The compact, portable handheld OCT probe can conveniently detect tissues in small spaces and flexibly move for point-of-care testing. In this review, the optical path design of the handheld probes is provided, and the requirements of the mechanical structure are analyzed. We also survey clinical applications in ophthalmology, stomatology, otology, and dermatology. The technical advances in multi-functional and multimodal imaging are presented. The future opportunities and challenges of the handheld OCT are discussed.
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