Abstract
We describe a novel dual-modality imaging approach that integrates diffuse optical tomography (DOT) and photoacoustic imaging (PAI) through a miniaturized handheld probe based on microelectromechanical systems (MEMS) scanning mirror. We validate this dual-modal DOT/PAI approach using extensive phantom experiments, and demonstrate its application for tumor imaging using tumor-bearing mice systematically injected with targeted contrast agents.
Highlights
Diffuse optical tomography (DOT) is an emerging modality capable of offering high contrast in both tissue absorption and scattering with centimeter penetration [1], while photoacoustic imaging (PAI) is a rapidly growing technique that can provide high resolution imaging of tissue absorption with millimeter penetration [2]
We describe a novel dual-modality imaging approach that integrates diffuse optical tomography (DOT) and photoacoustic imaging (PAI) through a miniaturized handheld probe based on microelectromechanical systems (MEMS) scanning mirror
We validate this dual-modal DOT/PAI approach using extensive phantom experiments, and demonstrate its application for tumor imaging using tumor-bearing mice systematically injected with targeted contrast agents
Summary
Diffuse optical tomography (DOT) is an emerging modality capable of offering high contrast in both tissue absorption and scattering with centimeter penetration [1], while photoacoustic imaging (PAI) is a rapidly growing technique that can provide high resolution imaging of tissue absorption with millimeter penetration [2]. We reported for the first time such approach in 2007 [12] and have seen several other studies in this regard [13,14,15]. These prior studies mostly were focused on a realization of combined DOT and photoacoustic imaging for large tissue imaging such as breast cancer detection. An example of small tissue imaging is image-guided surgery. In such case, DOT will be used to estimate the location/size of the deeply located tumors and PAI will be used to precisely identify the tumor margins when the imaging probe is close to the tumors
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