Handbook of Cell-Penetrating Peptides

Abstract

PART I Classes and Prediction of Cell-Penetrating Peptides, U. Langel Penetratins, E. Dupont, A. Prochiantz, and A. Joliot Tat-Derived Cell-Penetrating Peptides: Discovery, Mechanism of Cell Uptake, and Applications to the Delivery of Oligonucleotides, S. Abes, J.P. Richard, A. Thierry, P. Clair, and B. Lebleu Model Amphipathic Peptides, J. Oehlke, B. Wiesner, and M. Bienert Cell-Penetrating cis-g-Amino-L-Proline Derived Peptides, J. Farrera-Sinfreu, E. Giralt, M. Royo, and F. Albericio Prediction of Cell-Penetrating Peptides, M. Hallbrink and U. Langel PART II Classes and Prediction of Cell-Penetrating Peptides, A. Graslund Inverted Lipid Models: A Pathway for Peptide Internalization? G. Chassaing, S. Sagan, O. Lequin, A. Lamaziere, J. Ayala-Sanmartin, G. Trugnan, G. Bolbach, and F. Burlina Membrane Interactions of Cell-Penetrating Peptides, E. K. Esbjorner, A. Graslund, and B. Norden Interactions of Cell-Penetrating Peptides with Model Membranes, S. Deshayes, M.C. Morris, G. Divita, and F. Heitz The Import Mechanism of Cationic Cell-Penetrating Peptides and Its Implications for the Delivery of Peptide Inhibitors of Signal Transduction, M. Fotin-Mleczek, S. Voss, and R. Brock Mechanisms of Cargo Delivery by Transportans, M. Pooga, K. Padari, and U. Langel Tat-Mediated Peptide/Protein Transduction In Vivo, W. Shi and S.F. Dowdy Proteoglycans as Endocytosis Receptors for CPPs, M. Belting, A. Wittrup, and S. Sandgren PART III Functionality of Shuttling Proteins and Protein-Derived Peptides, A. Prochiantz Cell Permeable Peptides and Messenger Proteins, from a Serendipitous Observation to a New Signaling Mechanism, A. Prochiantz Pharmacology and In Vivo Efficacy of Pepducins in Hemostasis and Arterial Thrombosis, L. Covic, B. Tchernychev, S. Jacques, and A. Kuliopulos HOXB4 Homeoprotein Transfer Promotes the Expansion of Hematopoietic Stem Cells, S. Amsellem and S. Fichelson Applications of Cell-Penetrating Peptides as Signal Transduction Modulators, S. Jones and J. Howl SynB Vectors as Drug Carriers, J. Temsamani PART IV Applications of Cell-Penetrating Peptides in Gene Modulation and Protein Transport, S. F. Dowdy Peptide Conjugates of Oligonucleotide Analogues and siRNA for Gene Expression Modulation, J.J. Turner, A.A. Arzumanov, G. Ivanova, M. Fabani, and M.J. Gait Lego-Like Strategy for Assembling Multivalent Peptide-Based Vehicles Able to Deliver Molecular Cargoes into Cells, S.A. Waschuk, G.M.K. Poon, and J. Gariepy Mechanistic Insights into Guanidinium-Rich Transporters Entering Cells, J.B. Rothbard, T.C. Jessop, L. Jones, E. Goun, R. Shinde, C.H. Contag, and P.A. Wender Cell-Penetrating Short Interfering RNAs and Decoy Oligonucleotides, S. EL-Andaloussi, H. Johansson, P. Lundberg, and U. Langel A Noncovalent Peptide-Based Strategy for Peptide and Short Interfering RNA Delivery, M.C. Morris, S. Deshayes, F. Simeoni, G. Aldrian-Herrada, F. Heitz, and G. Divita PART V Selective Targeting to Tumors and Other Tissues with Cell-Penetrating Peptides: In Vivo Applications, E. Wagner Selective Delivery to Vascular Addresses: In Vivo Applications of Cell-Type-Specific Cell-Penetrating Peptides, P. Laakkonen and E. Ruoslahti In Vivo Applications of Cell-Penetrating Peptides, S. Moschos, A. Williams, and M.A. Lindsay Intracellular Delivery of Nanoparticles with CPPs, B. Gupta and V.P. Torchilin Strategies to Incorporate CPPs into Synthetic Viruses for Tumor-Targeted Gene Therapy, E. Wagner and M. Ogris Cell-Permeable Penta-Peptides Derived from Bax-Inhibiting Peptide, J. Gomez, V. Gama, and S. Matsuyama Cellular Uptake of Liposomal and Micellar Carriers Mediated by ApoE-Derived Peptides, M. Dathe, S. Keller, I. Sauer, and M. Bienert Imaging the Influx of Cell-Penetrating Peptides into the Cytosol of Individual Live Cells, S.R. Adams and R.Y. Tsien Microbial Membrane-Penetrating Peptides and Their Applications, A. Ganyu, U. Langel, and L. Good PART VI CPP Methods Design and Synthesis of Cell-Penetrating Peptides, Y. Jiang, U. Soomets, and U. Langel Toxicity Methods for Cell-Penetrating Peptides, K. Saar and U. Langel Methods to Study the Translocation of Cell-Penetrating Peptides, M. Lindgren, M. Pooga, and U. Langel Index