Halocyclization of Alkynoic Thioester and Oxidative Aromatization in One-Pot.

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This paper reports the halocyclization of alkynoic thioesters, as S-nucleophiles, with N-halosuccinimide, followed by oxidative aromatization with the same reagent for the one-pot synthesis of thiophenes, important heterocycles exhibiting remarkable applications in different disciplines. Brief mechanistic studies were also performed to elucidate the halocyclization process. The potential diverse applications of the product, dihydrothiophene, were also assessed.