Half-sandwich platinum group metal complexes containing coumarin-N-acylhydrazone hybrid ligands: Synthesis and biological evaluation studies

Abstract

A series of half-sandwich platinum group metal complexes containing coumarin-N-acylhydrazone ligands have been prepared. The metal precursors of the type [(p-cymene)RuCl2]2 and [Cp*MCl2]2 (M = Rh/Ir) and coumarin-N-acylhydrazone ligands (L1, L2 and L3) were reacted in the ratio of 1:2 (M:L), forming neutral bidentate (N ∩ O) complexes (1–9). The complexes are of the general formula [(arene)M{κ2(N∩O)L}Cl]. All these complexes have been characterized by analytical, spectroscopic and single-crystal X-ray diffraction studies. The complexes and ligands were then carried out for antibacterial, antioxidant and DNA binding studies. The results show that both ligands and complexes possess potent antibacterial and antioxidant properties.___________________________________________________________________________