Abstract
Objective: The purpose of this study was to determine the physical stability and effectiveness of hair growth in hair tonic preparations containing ethanol extract of clove leaves (Syzygium aromaticum) with a concentration variation of 5, 10, and 15%.
 Methods: Formulations were evaluated, including organoleptic observation, pH checking, and preparation stability tests using the Climatic Chamber. The effectiveness of clove leaf extract as a hair tonic was tested by looking at hair growth in test animals.
 Results: The results showed that the preparation was stable at high temperatures (40±2 °C) where the odor, color, clarity, and pH remained constant. Effectiveness test on rabbit hair growth showed significantly different results after measuring hair growth on the 21st day, where the results were 11.83+0.06 mm for positive control, 1.71+0.06 mm as blank, 1.69+0.06 mm for the group without treatment, and successively the results of the group given clove leaf extract 5, 10, and 15% were 4.00+0.06; 4.80+0.06; and 5.46+0.08 mm.
 Conclusion: Hair tonics containing clove ethanol extract can increase rabbit hair growth.
Highlights
Hair loss is a condition where the hair is detached from the surface of the skin, such as the head and body
Hair loss can be caused by heredity and the influence of hormones
One way to prevent hair loss is by doing hair care
Summary
Hair growth stimulants (hair tonic) are preparations that contain ingredients needed by hair, hair roots and scalp [1, 2]. Phenolic and flavanoid compounds in each plant have a role to stimulate hair growth [19,20,21]. In this article we will discuss the activity of clove leaf extract in triggering hair growth or as a hair tonic. The solvent used was 96% ethanol, and the other chemicals were sodium metabisulfite, methyl paraben, propyl paraben, menthol, tween 80, propylene glycol and distilled water.
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