Abstract
Objective: Previous research has proven that the water fraction of the Angiopteris evecta root has hair growth activities. The objective of this research was to determine the formula of gel and hair tonic preparations of pakis munding (Angiopteris evecta L.) which met the requirements as a pharmaceutical preparation, good and effective in stimulating hair growth.
 Methods: Formulation of hair tonic and gel preparations were made using 7.5, 10.0, and 12.5 % of A. Evecta root water extracts as active compounds. The formulation of the two preparations was based on the standard formulation method. The evaluation and formulation test were carried out by organoleptic examination and homogeneity, pH, viscosity, scattering power test, stability test, and safety test based on the standard preparations including Indonesian pharmacopeia. Statistical tests were carried out on both formulas against rabbits based on the modification of the Tanaka method. Comparison of statistics on both formulas was also carried out.
 Results: It was found both formulas fulfill standard requirements as pharmaceutical preparations. Statistically, the best activity in hair tonic preparations was at a concentration of 12.5% and for gels at a concentration of 10.0% ethanol extract seen from measurements of hair length. Statistically, using the Independent T-test to find out the significant differences in the average hair length on hair tonic and gel, it was found there was no significant difference between the two formulas. It was found that the best formula for hair tonic and gel was in the addition of 10.0% and 12.5% extracts, respectively.
 Conclusion: The results obtained in this research work clearly indicated that both hair tonic and gel formulas of A. evecta root water extract may be used as stimulating hair growth.
Highlights
To overcome baldness, various methods are carried out, one of which is the innovation of synthetic hair growth formula and herbal products
There was no significant difference from the average rabbit hair length for each group
With the same calculation applied to the gel formulation, it was found statistically that the hair tonic formula with 12.5% water fraction, Gel formula with 10.0% water fraction was the best application and there was no significant difference between the formula of hair tonic and gel
Summary
Various methods are carried out, one of which is the innovation of synthetic hair growth formula and herbal products. The use of these types of material has been widely produced, so in the market today there are many hair growth drugs. Based on the research conducted Mustarichie et al [5] pakis munding (Sundanese) roots have activities to grow hair. Tresnawati [6] mentioned that pakis munding roots contain flavonoids, saponins, polyphenols, tannins, quinones, monoterpenes and sesquiterpenes and water fraction with a concentration of 7.5%, 10%, and 12.5% having the good hair growth activity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
