Abstract
The haematological and haemostatic effect of the aqueous extract of Gongronema latifolium was investigated. Twenty-eight (28) albino rats weighing 180-200g were divided into three groups; A (8 rats), B (10 rats) and C (10 rats). The group A served as control and was given normal rat pellet and water ad libitum while the test groups B and C were given 1.0 ml of the aqueous extract of Gongronema latifolium in combination with the normal rat pellet and water and a low and high dose respectively. The feeding process lasted for 28 days. On the 29 th day, 2.0ml of blood sample was collected by cardiac puncture for haematological analysis after a cut was made on the tail of the rats using a lancet and blade. The blood samples was used for the analysis of the haemostatic indices. The result showed that the mean haemoglobin concentration, packed cell volume, platelet count and total white blood cell count significantly decreased at P<0.05. Also there was a significant decrease in the mean value of bleeding and clotting time at P<0.05. This decrease was found to be dose dependent.
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