Abstract
Gynecologic malignancies represent 12% of cancers diagnosed in woman, with endometrial cancer being the most common. This chapter aims to discuss the dosimetric and clinical data that are currently available for proton therapy in gynecologic cancers, present institutional planning techniques and considerations when treating gynecologic cancers with proton therapy, and discuss some of the challenges and future directions of proton therapy in gynecologic malignancies. Radiation therapy plays a key role in the treatment of gynecologic malignancies and is often combined with chemotherapy. There are ongoing clinical trials investigating whether there is a reduction in toxicity with proton therapy for the adjuvant treatment of endometrial or cervical cancer. More studies are needed to explore the role of proton therapy in gynecologic malignancies.
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