Abstract
Microbial invasion of the skin and underlying soft tissues, known as skin and soft tissue infections (SSTIs), contribute to a considerable burden of disease worldwide (Kaye et al., 2019; Lozano et al., 2012). Knowledge about host factors contributing to SSTI risk is important to prevent the SSTIs. The genetics of SSTI susceptibility remain largely unknown, and the only previously published genome-wide study on SSTIs is a small family-based linkage study that did not identify significant linkage to any genes for erysipelas or cellulitis susceptibility (Hannula-Jouppi et al., 2013).
Highlights
Vergnano M, Mockenhaupt M, Benzian-Olsson N, Paulmann M, Grys K, Mahil SK, et al Loss-offunction myeloperoxidase mutations are associated with increased neutrophil counts and pustular skin disease
A range of cardiometabolic risk factors has been associated with soft tissue infections (SSTIs) (Butler-Laporte et al, 2020; Kaye et al, 2019; Winter-Jensen et al, 2020)
Increasing body mass index has been found to increase the risk of SSTIs in such a framework (Butler-Laporte et al, 2020; Winter-Jensen et al, 2020), but other cardiometabolic risk factors have, to our knowledge, not been explored
Summary
Vergnano M, Mockenhaupt M, Benzian-Olsson N, Paulmann M, Grys K, Mahil SK, et al Loss-offunction myeloperoxidase mutations are associated with increased neutrophil counts and pustular skin disease. GWAS Identifies LINC01184/SLC12A2 as a Risk Locus for Skin and Soft Tissue Infections Journal of Investigative Dermatology (2021) 141, 2083e2086; doi:10.1016/j.jid.2021.01.020
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