GW29-e0421 An increase in CO2 levels by upregulating the late sodium current is proarrhythmic in the heart

Abstract

Increased CO2 levels in the myocardium are common under pathological conditions. Previous studies have reported that acidosis is associated with ventricular arrhythmias and has an effect on late sodium current (INa,L). Whether increased CO2 levels alone are arrhythmogenic remains to be investigated