Abstract
Diabetes is a common disease characterized by high blood glucose level, combined with metabolic disorder of carbohydrates, lipids, proteins and other substances. The relationship between the human gut microbes and diabetes is still not clear. Human intestinal tracts harbor trillions of microbes that maintaining a symbiotic relationship with the host. Gut microbiota not only helps the host to digest certain food, but also produces a large number of biologically active signaling molecules involved in immune regulation, anti-tumor, anti-aging regulation, which are also related to the pathogenesis of diabetes. These molecules can be used as targets for prediction, diagnosis and treatment of diabetes. Metabolomics, as a rising technology to study the changes of metabolites in human body quantitatively, can be a helpful tool for researchers in this area. This article reviews recent progresses about mechanism and emerging interventions of diabetes mellitus from the perspective of metabolism of gut microbiota.
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