Abstract
Polyphenols health effects on obesity are mainly attributed to their metabolites generated after their gastrointestinal digestion, in which gut microbiota plays an important role. Moreover, gut microbiota composition and polyphenols bioavailability are influenced by differences in day light length (photoperiod). Thus, this study evaluates if a grape seed proanthocyanidins (GSPEs) extract bioavailability is influenced by different photoperiod exposure via gut microbiota modulation in an obesogenic context. Cafeteria diet-induced obese Fischer 344 rats are housed under different photoperiod conditions (6, 12, or 18h of light per day) during 9weeks and administered with GSPE (25mgkg-1 ) or GSPE and an antibiotic cocktail (ABX) for the last 4weeks. Serum GSPE-derived metabolites are quantified by HPLC-MS/MS. A higher bioavailability is observed under 6h light/18h darkness (L6) compared to 18h light/6h darkness (L18). Individual metabolites, especially those from the gut microbiota, are affected by photoperiods. ABX treatment alters these photoperiod-mediated changes. Therefore, these results suggest that gut microbiota plays a key role in the photoperiod effects on GSPE bioavailability in obese rats.
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